ETHYL (S)-PYROGLUTAMATE
H-Pyr-OEt
CAS: 7149-65-7
Molecular Formula: C7H11NO3
ETHYL (S)-PYROGLUTAMATE - Names and Identifiers
| Name | H-Pyr-OEt |
| Synonyms | H-Pyr-OEt H-PYR-OET ETHYL L-PYROGLUTAMATE Ethyl L-pyroglutamate ethyl 5-oxo-L-prolinate ETHYL (S)-PYROGLUTAMATE L-PYROGLUTAMIC ACID ETHYL ESTER ETHYL (S)-2-PYRROLIDONE-5-CARBOXYLATE ETHYL (S)-2-PYRROLIDINONE-5-CARBOXYLATE (S)-(+)-5-Ethylcarboxyl-2-pyrrolidinone ETHYL (S)-(+)-2-PYRROLIDONE-5-CARBOXYLATE |
| CAS | 7149-65-7 |
| EINECS | 230-480-9 |
| InChI | InChI=1/C7H11NO3/c1-2-11-7(10)5-3-4-6(9)8-5/h5H,2-4H2,1H3,(H,8,9) |
ETHYL (S)-PYROGLUTAMATE - Physico-chemical Properties
| Molecular Formula | C7H11NO3 |
| Molar Mass | 157.17 |
| Density | 1.2483 (rough estimate) |
| Melting Point | 54-56°C |
| Boling Point | 176°C12mm Hg(lit.) |
| Specific Rotation(α) | -3.5 º (c=5, water) |
| Flash Point | >230°F |
| Appearance | Low Melting Solid |
| Color | White to cream |
| BRN | 82621 |
| pKa | 14.78±0.40(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.4310 (estimate) |
| MDL | MFCD00064497 |
ETHYL (S)-PYROGLUTAMATE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 3-10 |
| HS Code | 29339900 |
ETHYL (S)-PYROGLUTAMATE - Reference Information
| Introduction | ethyl L-pyroglutamate is a white to cream colored, low melting solid that is a non-natural amino acid derivative, unnatural Amino acids have been used in bacteria, yeast and mammalian cells for protein modification, which have been applied in basic research and drug development, biological engineering and other fields, it is widely used to detect protein structural changes, drug coupling, biosensors and so on. |
| Use | ethyl L-pyroglutamate can be used as pharmaceutically active molecules and intermediates in organic synthesis, for example, synthetic biologically active molecules such as HIV integrase inhibitors. In the synthetic conversion, the nitrogen atom in the amide group may be coupled with iodobenzene, and the hydrogen on the nitrogen atom may be converted into a chlorine atom. In addition, the ester group may be converted into an amide product by a urethane exchange reaction. |
| synthetic method | add L-pyroglutamic acid (5.00g), P-toluenesulfonic acid monohydrate (369 mg, 1.94 mmol) and ethanol (100 mL) were stirred overnight at room temperature, the residue was dissolved in 500 EtOAc, the solution was stirred with potassium carbonate and (after filtration), the organic layer was dried over MgSO4, and the organic phase was concentrated in vacuo to give ethyl L-pyroglutamate. Figure 1 synthesis of ethyl L-pyroglutamate |
Last Update：2024-04-09 18:58:34
Supplier List
Product Name: H-Pyr-OEt Request for quotation
CAS: 7149-65-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 7149-65-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Product Name: Ethyl (S)-(+)-2-pyrrolidone-5-carboxylate Visit Supplier Webpage Request for quotation
CAS: 7149-65-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 7149-65-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: H-Pyr-OEt Request for quotation
CAS: 7149-65-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 7149-65-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Product Name: Ethyl (S)-(+)-2-pyrrolidone-5-carboxylate Visit Supplier Webpage Request for quotation
CAS: 7149-65-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 7149-65-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History